Technical Capabilities

Enable Life Sciences offers a wide array of technical capabilities within the life sciences space – by virtue of operating on a flexible project team structure composed of highly qualified and experienced independent consultants.

Project teams are assembled on a customized basis, based on the specific project needs of our clients. Our flexible project-staffing model allows us to engage subject matter experts on a case-by-case basis, per the unique needs of each project.

In addition to its ability to assemble customized and highly qualified project teams, Enable Life Sciences also has access to the following Core Research Facilities (CRFs) within the state of Massachusetts. These Core Research Facilities (CRFs), engaged on a fee-for-service model, allow us to access a wide array of scientific instrumentation, technicians, and subject matter experts.

Some areas of our technical capabilities are mentioned below, with more being added constantly. Please reach out to us for a customized project proposal.

Analytical

High performance liquid chromatography (HPLC)

Gas Chromatography (GC)

Gel permeation chromatography (GPC)

Nuclear magnetic resonance (NMR)

ICP-MS (Inductively Coupled Plasma – Mass Spectrometry)

Dissolution Testing

Material characterization and surface analysis, including but not limited to:

  • XPS (X-ray photoelectron spectroscopy)
  • Optical Profilometry
  • AFM (Atomic Force Microscopy)
  • DSC (Differential Scanning Calorimetry)
  • TGA (Thermo-Gravimetric Analysis)
  • FTIR (Fourier Transform Infrared Spectroscopy)
  • Scanning Electron Microscopy (SEM)

Particle analysis, including:

  • Coulter counting
  • Single particle optical sensing (SPOS)
  • Differential light scattering (DLS)
  • Laser Diffraction

Medical Devices and (Bio)-pharmaceutical Development

Pre-formulation and formulation with small-molecule and biomolecule therapeutics

Sustained-release drug delivery systems

Biomolecule conjugation

High throughput screening (HTS) of therapeutic libraries

Extractables and Leachables testing and analysis

Impurity analysis

Medical device coatings

Polymer processing

3-D prototyping for medical devices

Molecular Biology and Cell Culture

Biomolecule (including protein) expression, scale-up and purification

Biomolecule (including protein) chemistry; affinity column separation; dialysis

Biomolecule (including protein) stability-analysis and characterization

Cell culture models, and cell-based in vitro assay development

Western, Northern blotting

ELISA and Luminex analysis for biomarker profiles

Flow cytometry

In vivo Evaluation and analysis

Pre-clinical: design and implementation of animal experiments (mice, sheep, porcine models)

Tissue processing, embedding and sectioning

Histology

Statistical analysis

Clinical study design and data analysis